Azole resistance in Aspergillus fumigatus: the next step

Announcement Workshop Azole Resistance 2019

Azole resistance is a concern for the management of diseases caused by Aspergillus fumigatus in humans. Azole fungicide use in the environment has been identified as possible cause for resistance development, and thus increases the complexity and number of stakeholders involved in this emerging problem. We aim to bring together relevant stakeholders including medical and agricultural researchers, representatives from the government, fungicide producers and users, and public health to review the current evidence supporting environmental resistance selection and to discuss which research and measures are needed to retain the azole class for environmental and medical applications.

prof. P. Verweij
prof J. Lucas
dr B. Fraaije
prof B. Zwaan

31 January & 1 February 2019
Trippenhuis Royal Netherlands Society of Arts and Sciences
Amsterdam, The Netherlands

programme 31 January 2019

The patient
Chair: prof. K. Lagrou
09:00 Welcome and aims of the meeting prof. P. Verweij
09:10 Aspergillosis and the global burden of disease prof. D. Denning
09:30 Invitro susceptibility testing and surveillance prof. M. Arendrup
09:50 Medical implications of resistance and management prof. P. Verweij
10:10 Diagnostic challenges and possible solutions dr. W. Melchers

10:30 break

10:50 The lung mycobiome prof. P. Bowyer
11:10 Azole resistance in the global AMR perspective t.b.a

11:30 Consensus discussion – medical needs

12:00 Lunch

The environment
Chair: prof. P. Dyer
13:00 Resistance risk assessment model revisited prof. U. Gisi
13:20 Fungicide resistance in different habitats and produce dr. B. Fraaije
13:40 Azole resistance and the concept of hotspots prof. B. Zwaan

14:00 break

14:20 Whole genome sequencing to unravel the origin and spread of resistance mutations dr. J. Rhodes
14:40 Experimental evolution experiments as tool to understand resistance selection dr. S. Schoustra
15:00 Fungicide resistance risk evaluation, resistance management – FRAC position dr. K. Stenzel

15:30 Break-out session 1
I – Resistance selection environments: the concept of the hotspot
II – From hotspot to lung lesion: relation between environment and human aspergillus disease

16:30 Reporting back and round-up day 1

17:30 Closing

programme 1 February 2019

Stakeholder views
Chair: dr. A. Rietveld
9:00 Fungicide Product Stewardship in the flower bulb sector  Ir. E. Kiers
9:20 Fungicide use in hot spots, example flower bulb production process drs. A. Hoogendijk
9:40 Connection to compost production as natural habitat of Aspergillus Ir. A. Brinkmann

10:00 break

10:20 Authorization of fungicides dr. Ir. P. Geenen

10:40 General discussion

11:00 Break-out session 2
I – Which research is needed?
II – Which measures are needed?

12:00 Lunch

13:30 Integrated research plan and prioritization
Chair: prof. J. Lucas
Prevention of resistance selection – risk matrix and hot spot areas, hot spot processes e.g. composting; Antifungal stewardship; Fungicide replacement; Diagnostic tools; Resistance surveillance; resistance management measures in medical and non-medical areas, Fungicide authorization procedure

15:30 Priorities and summary

16:00 Closing

Announcement Workshop Azole Resistance 2019


  • Wanneer 31 januari - 1 februari 2019
  • Waar Het Trippenhuis, Kloveniersburgwal, Amsterdam, Nederland
  • Categorie

Azole resistance in Aspergillus fumigatus: the next step
31 januari - 1 februari 2019

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